Genetically Engineered

Alec
(from Dark Angel)

What: X-Series (X5-494)
Abilities: Enhanced sight, speed, strength and reflexes.
Flaws: His "twin" became a serial killer.

Max Guevera
(from Dark Angel)

What: X-Series (X5-452)
Abilities: Enhanced sight, speed, strength and reflexes.
Flaws: Seizures (which were fixed after being recaptured) and mating cycles similar to a cat.

Ryuuji Iwasaki
(from Tokumei Sentai Go-busters)

What: Blue Buster
Abilities: Super Strength
Flaws: Must not allow himself to overheat. In the event that he does, Ryuuji will become uncontrollable and rampage.

Will Aston
(from Power Rangers: Operation Overdrive)

What: Power Ranger
Abilities: Enhanced sight and hearing.
Flaws: None

John Brown
(from Inspector Gadget)

What: Inspector Gadget
Abilities: Various
Flaws:

Joshua
(from Dark Angel)

What: The first transgenic.
Abilities: Enhanced strength and smell.
Flaws: Half man, half dog.

Dillon
(from Power Rangers: R.P.M.)
What: Subject D-44
Abilities: Enhanced strength and reflexes
Flaws: As his implants spread, he will have less control over his actions.

Yuriko Oyama / Lady Deathstrike
(from X2: X-Men United)

What: Enhanced Mutant
Abilities: Adamantium bones, with retractable fingernails.
Flaws: Unknown

Logan / Wolverine
(from the X-Men franchise)

What: Weapon X
Abilities: Adamantium bones, with retractable claws.
Flaws: It always hurts when the claws come out.

Darth Vader
(from the Star Wars franchise)
What: Cyborg
Abilities: None, he already has the force.
Flaws: He cannot survive outside of the suit.

Alice
(from the Resident Evil series)

What: A former Umbrella employee, infected with their T-Virus.
Abilities: Telekinesis
Flaws: Still mortal and unable to properly be recreated.

Tenaya
(from Power Rangers: R.P.M.)
What: Super Villain / Subject T-78
Abilities: Detachable hand, voice modification, working eyes.
Flaws: She's not entirely machine like she thinks she is.

Yoko Usami
(from Tokumei Sentai Go-busters)

What: Yellow Buster
Abilities: Super Jump
Flaws: Must eat sweets to keep her calorie intake up. If not, she becomes too weak to move.

Zack
(from Dark Angel)

What: X-Series (X5-499)
Abilities: Enhanced sight, speed, strength and reflexes.
Flaws: Seizures (which were fixed after being recaptured) and being a living donor.

Steve Austin
(from The Six Million Dollar Man)

Rose Ortiz
(from Power Rangers: Operation Overdrive)

What: Power Ranger
Abilities: Invisibility.
Flaws: None.

Ronny Robinson
(from Power Rangers: Operation Overdrive)

What: Power Ranger
Abilities: Super speed.
Flaws: None.

Astronema
(from Power Rangers in Space)
What: Super Villain
Abilities: No enhancements, just a brainwashing.
Flaws: The implants are unable to be safely removed.

Wade Wilson / Deadpool
(from X-Men Origins: Wolverine)
What: Weapon XI
Abilities: Various powers from other mutants.
Flaws: None, apparently.

Jaime Sommers
(from Bionic Woman)

What: Bionic Woman #2
Abilities: Bionic legs, arm, ear and eye.
Flaws: Short lifespan.

Sarah Corvus
(from Bionic Woman)

What: Bionic Woman #1
Abilities: Almost entirely Bionic.
Flaws: Short lifespan.

Julian Bashir
(from Star Trek: Deep Space Nine)

Hiromu Sakurada
(from Tokumei Sentai Go-busters)

What: Red Buster
Abilities: Super Speed
Flaws: Freezes whenever he sees a chicken, or hears the word.

Jaime Sommers
(from The Bionic Woman)

What: The Bionic Woman
Abilities: Bionic legs, arm and ear.
Flaws:

Dax Lo
(from Power Rangers: Operation Overdrive)

What: Power Ranger
Abilities: Super bounce
Flaws: Other than the fact he has super bounce? None.