Serial Co-Stars

Leonardo DiCaprio and Kate Winslet were an unforgettable duo in 1997's Titanic, and they tried to recapture the onscreen chemistry more than a decade later in the 2008 flick Revolutionary Road. Though their second flick didn't drum up quite the same numbers at the box office, the film was well-received by critics and Winslet won the Golden Globe for Best Lead Actress.

These two teamed up for How to Lose a Guy in 10 Days in 2003, then again in 2006 for Fool's Gold. We'd like to point out that Matthew McConaughey went shirtless at some point in both films. Shockingly, no one complained

Kristen Stewart and Dakota Fanning have starred in a whopping five more flicks together since first starring in the 2007 short film Cutlass. The gals play enemies in four Twilight movies then teamed up as bandmates in the 2010 film The Runaways.

People really love Adam Sandler and Drew Barrymore's onscreen chemistry. The duo won the 1998 MTV Movie Award for Best Kiss in The Wedding Singer, then they scored the 2004 award for Best On-Screen Team after starring in 50 First Dates.

Richard Gere and Julia Roberts have fallen in love twice on the big screen. The first time, Roberts played a call girl in the 1990 hit Pretty Woman and they paired up again for 1999's Runaway Bride. Their second flick made plenty of money at the box office, but it failed to become a cult classic like their first onscreen romance.

Christina Ricci and Johnny Depp have technically been in three flicks together, though their joint screen time in The Man Who Cried and Fear and Loathing in Las Vegas was minimal. They both played main characters in Sleepy Hollow, however.

Ben Stiller and Owen Wilson have been in six films together -- and counting. Their joint comedies include: The Royal Tenenbaums, Zoolander, and Starsky & Hutch, along with the Meet the Parents franchise. Stiller said in a past interview: "We just enjoy each other's company and have fun working together. As long as people seem to allow us to work together, I think it will kinda keep going."

Sandra Bullock and Keanu Reeves first teamed up for the action flick Speed in 1994 and 12 years later they reunited in the time travel film The Lake House. Reeves said the first time they met "it was two actors in a room pretending to drive a bus and falling on the ground." They joked that their third movie together should be a "little '40s musical."

Brad Pitt and George Clooney seem to strike box office gold pretty much every time they star in a movie together. Their charm and dashing good looks probably have nothing to do with it. You can catch this duo in 2008's Burn After Reading and Ocean's 11 - 13.

These two first starred in Babel together in 2006, then they played life-long lovers traveling along opposite timelines in The Curious Case of Benjamin Button two years later. After that, Cate joked about refusing to work with Mr. Pitt again. "Honestly," she said, "to see how in love with Angelina he is, it was really quite disgusting. Awful in fact. It's in my contract now: I won't ever work with him again.

Tom Cruise and Nicole Kidman met while filming 1990's Days of Thunder, and they got married on Christmas Eve that year. They starred in the 1992 flick Far and Away and 1999's Eyes Wide Shut before divorcing in 2001

Meg Ryan and Tom Hanks first fell in love on the big screen in 1990's Joe Versus the Volcano, and have done so twice more. They met up at the Empire State Building in 1993's Sleepless in Seattle, then met online in the early days of the internet in 1998's You've Got Mail

A year after Halle Berry and Hugh Jackman kicked butt as Storm and Wolverine in X-Men, they joined forces in Swordfish. Then they reprized their superhero roles in 2006's X-Men: The Last Stand

Vince Vaughn and Will Ferrell started a fraternity in Old School, then they schemed about how to get girls in Wedding Crashers. Both flicks were comedic gold, and we expect to see the funny dudes collaborate again in the future. Ferrell has also starred in a slew of movies with John C. Reilly. Think Step Brothers and Talladega Nights.

Helena Bonham-Carter is married to director Tim Burton, who often casts pal Johnny Depp in his movies, so it's no big surprise that the actors have been in a slew of films together. Their works include Alice in Wonderland, Sweeney Todd, and Charlie and the Chocolate Factory. Fun Fact: Depp is the godfather to both of Burton's kids