Osmosis Jones [2001] - Region 2 DVD

Osmosis Jones is about two-thirds animation and one-third live action, which is why two-thirds of the film is entertaining and funny, and one-third is not. The life Osmosis and Drix save belongs to Frank, a slob played in live-action sequences by Bill Murray, who's undercut rather than supported by Chris Elliott and Molly Shannon. Shamelessly over-the-top performances make the human characters seem flatter than the two-dimensional cartoons. The live action was shot by the Farrelly brothers and features lots of gross-out gags about zits, flatulence, vomit, etc. The audience endures these leaden segments, waiting to get back to the animation--and the real comedy. Suitable for ages 9 and up: profanity, violence, bodily function jokes. --Charles Solomon, Amazon.com