Get Down With OCD!

as Melvin Udall in As Good As It Gets

Funny, but kind of a freak show portrayal of OCD.

as Roy Waller in Matchstick Men

(Sigh) Another OCD freak show. At least Jack Nicholson was funny as an obsessive-compulsive.

as Adrian Monk in Monk

Finally! An accurate portrayal of OCD. While there is still exagerration for comedic purposes, Monk humanized OCD. As Tony Shalhoub is great in every role, it's not surprising. Kudos, Tony!

as Harold Krenshaw in Monk

While more comedic on average than Monk himself, Tim Bagley also did a great job.

as Sheldon Cooper in the Big Bang Theory

Name a psychological disorder, there's a good chance Sheldon has it.

as Robert McCall in the Equalizer

What do you get when you combine Adrian Monk and Bryan Mills (Liam Neeson's character in Taken)? You get Robert McCall.
Of course, you can count on Denzel Washington nailing any role.