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Amazing
The Adventures of Batman & Robin - Sega Genesis and Mega Drive
This crazy hard game also boasts a lot of crazy neat special tricks
Ranger X - Sega Genesis and Mega Drive
Incredible special effects and use of Sega Genesis palette and other special features, like horizontal scrolling of parallaxes and shadow/highlight mode
Red Zone - Sega Genesis and Mega Drive
It even tells in a text screen all the crazy special effects it does
Gunstar Heroes - Sega Genesis and Mega Drive
Lots of special effects and a lotta sprites on-screen.
Paulo Júnior's rating:

Formula One - Sega Genesis and Mega Drive
Domark made a very playable polygonal racing game on Genesis! And for 2 players nonetheless.
F1: World Championship Edition - Sega Genesis and Mega Drive
Domark made yet another, maybe even better, polygonal racing on MD.
Castlevania: Bloodlines - Sega Genesis and Mega Drive
Konami put a lot of neat special effects in this
Paulo Júnior's rating:

YūYū Hakusho: Makyō Toitsusen - Sega Genesis and Mega Drive
4 players on the same screen, on two planes, with good graphics and the stages even vary during the fight (afternoon to evening for example)
Paulo Júnior's rating:

Alien Soldier - Sega Genesis and Mega Drive
Being a game from Treasure, it has a lot of special effects
Virtua Racing - Sega Genesis and Mega Drive
Using the special chip SVP - Sega Virtua Processor - it allowed a somewhat faithful conversion from this polygonal arcade game
Bloodshot - Sega Genesis and Mega Drive
The less terrible first person shooter on the system. It also features f***ing split-screen, coop or competitive, for 2-players!
Light Crusader - Sega Genesis and Mega Drive
This Treasure game is lighter on special effects, but it still boasts the goods, even polygons
Dynamite Headdy - Sega Genesis and Mega Drive
Treasure does its usual and uses a lot of tricks to show special effects
Mickey Mania : The Timeless Adventures of Mickey Mouse... - Sega Genesis and Mega Drive
A lot of special effects, some of which are explained in Jon Burton's Gamehut YouTube channel
Vectorman - Sega Genesis and Mega Drive
Not only does it have lightning effects, but it also does other impressive tricks and uses metasprites a lot
Paulo Júnior's rating:

Dick Vitale's "Awesome, Baby!" College Hoops - Sega Genesis and Mega Drive
Mode-7-like choppy basketball game
Pier Solar and the Great Architects - Sega Genesis and Mega Drive
Being the biggest Sega Genesis game to date, and released years after the console was officially discontinued, it has a lot of good uses of the hardware. Even a mode-7-like effect
Mega Turrican - Sega Genesis and Mega Drive
It boasts some neat graphical tricks that impress.
Paulo Júnior's rating:

The games that show how powerful the Mega Drive really was.
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