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Monster World IV - Sega Genesis and Mega Drive
Released only in Japan.
Wonder Boy VI
Paulo Júnior's rating:

Generations Lost - Sega Genesis and Mega Drive
I've found this game to be awesome.
Paulo Júnior's rating:

Minnesota Fats: Pool Legend - Sega Genesis and Mega Drive
Side Pocket is a very well-known game, but this game, its sequel, is rather unknown.
Pocahontas - Sega Genesis and Mega Drive
Based on the animated movie of the same name. It's a neat puzzle platformer.
Rent A Hero - Sega Genesis and Mega Drive
Released only in Japan by Sega. There is a fan translation on the net now.
Weaponlord - Sega Genesis and Mega Drive
By Namco, it's basically the 2D predecessor to Soul Calibur.
Nickelodeon: Aaahh!!! Real Monsters - Sega Genesis and Mega Drive
Based on Nickelodeon cartoon of same name.
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Sega Mega Drive's underground, unknown games. Some are even underrated. Some even weren't released outside asian regions.
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