Jane Wyman as Belinda McDonald (Deaf Mute)
Patty Duke as Helen Keller (Blind, Deaf Mute)
Marlee Matlin as Sarah (Deaf)
Holly Hunter as Ada McGrath (Mute)
Nicholas John Renner as Coltrane 'Cole' Holland, age 6 (Deaf)
Samantha Morton as Hattie (Mute)
Elaine Cassidy as Lydia (Mute)
Spencer Treat Clark as Silent Ray Harris (Mute)
Rinko Kikuchi as Chieko Wataya (Deaf)
Dillon Freasier as HW (Deaf)