Howling II - Your Sister Is a Werewolf - Region 1 DVD

After newscaster Karen White's shocking on-screen transformation and violent death (in the original The Howling), her brother Ben (Reb Brown) is approached by Stefan Crosscoe (Lee), a mysterious man who claims that Karen has, in fact, become a werewolf. But this is the least of their worries... To save mankind, Stefan and Ben must travel to Transylvania to battle and destroy Stirba (Danning), the immortal queen of all werewolves, before she is restored to her full powers!