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A young girl named Cathy (Jenny Neumann) tries to keep her mother from making out with a man while driving one day, and she inadvertently causes her mother's death in the ensuing crash. Sixteen years later, Cathy is now named Helen and has become a psychotic actress. Since her mother died with a shard of glass in her throat, Helen begins hacking through the cast of her new play, "Comedy of Blood," in similar fashion.