85. Mysterio

Mysterio, who first came on the scene in Amazing Spider-Man #13, has made it his life goal to piss off Spider-Man, and he's done a good job of it. Also known as Quentin Beck-he faked Aunt May's death, scared her into thinking she was being attacked by aliens, convinced Spider-Man he was 6 inches tall using hypnosis and tricked Spidey into believing he killed a guy.

After believing Spider-Man was a clone, he turned his interests over to Daredevil. Like Spider-Man, Mysterio's goal was to turn him insane. He almost got him to kill a baby he falsely believed was the Antichrist, convinced Matt Murdock's secretary/love interest Karen Page that she had contracted HIV from her time as a porn star and manipulated Murdoch's law partner Foggy Nelson into having an affair, and then frames him for killing the girl. Like any good magician though, he doesn't like to be called a copycat. After Daredevil exposed Mysterio and told him Kingpin had already done all that stuff, he shot himself. There were two other Mysterios but they aren't all that interesting. A stunt man and guru of special effects, he was on the fast track to becoming a major player in Hollywood but saw it as a dead end career. Through his magic and hypnotism past and with the help of a general knowledge of chemistry and robotics, on top of the combat techniques he learned as a stuntman, these abilities together make the otherwise regular human Quentin Beck a qualified opponent of Spider-Man. He created a gas that could cancel out his spider-sense and his suit had that well-known helmet with a holographic projector and gloves armed with hallucinogenic gas. You can call him Fish Bowl Head Guy, though.