In Kingdom of the Spiders a swarm of huge tarantulas, enraged by the misuse of pesticides, try to take over their part of the world. Dr. Robert Hansen (William Shatner), a local Arizona veterinarian joins forces with entomologist Diane Ashley (Tiffany Bolling) to keep the spider population under control. Woody Strode and Altovise Davis also appear as the owners of a neighboring ranch.