Phalanx - Game Boy Advance

Phalanx is not a typical arcade shooter. It is designed to push players to the extreme limits of their skills. But even if you don't have genetically altered reflexes, you can still find the appropriate difficulty level, and work your way to the skills necessary to save the universe. There are cut scenes with an engaging storyline and slowly building drama, and eight varied missions.

Manufacturer's Description
A mysterious alien race has seized the colony of Delia IV, the solitary Terran planet in the outer frontier arm of the Andromeda Galaxy. You are Riki Sanada, a genetically enhanced pilot with reactions thirty-three times faster than ordinary humans. You exist solely to fly the Phalanx A-144; a prototype strike fighter equipped with the most advanced weapons ever created. The Andromeda arm is teeming with an armada of powerful alien spacecraft. You're the only Terran pilot for thousands of light-years.

That should make the odds just about even.