Tsunade

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Tsunade is the Fifth Hokage of Konohagakure — a position which she succeeded after the death of her teacher, Hiruzen Sarutobi, and a major supporting character of the series. She hails from the village's Senju clan, and is also a descendant of the Uzumaki clan through her grandmother Mito. Along with former team-mates Jiraiya and Orochimaru, she is recognised as one of the "Three Legendary Shinobi". Tsunade is considered to be the most powerful kunoichi in the world, and is celebrated as the greatest medical-nin of all time, credited with creating the official system which governs them.