The Master

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The Master — known in female form as Missy, short for Mistress, and at times by various other aliases — was a renegade Time Lord, originally a friend and long an opponent of the Doctor.

Though they had been friends from childhood and schoolmates at the Academy before falling out, the Master developed an intense hatred for and often sought to kill the Doctor, who came to regard the Master as his arch-enemy. Despite this enmity, however, the Master and the Doctor would on occasion act as allies.

The Master's diabolical madness was at least partially the result of a genuine malady in the form of a never-ending drumming sound that had been retroactively implanted inside his head by Rassilon and the High Council on the final day of the Last Great Time War to further their own goals.