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Cryptosporidium, commonly known as simply Crypto, is a Furon warrior and the playable villain-protagonist of the Destroy All Humans! series. Crypto's history is unknown up to the events of him arriving on Earth. Apparently, he has a mother, who according to him is very unloving. He also worked with Orthopox for quite some time before coming to Earth. His story can be divided by the number of clones he's had.

Crypto's most obvious trait is his taste for destruction, making him an effective soldier for the Furon Empire. Needless to say, he's very sadistic, taking pleasure from torturing human beings. While he started out hating all things human, he later develops a more relaxed attitude due to spending years mingling with humanity (and even becoming romantically involved with a human female named Natalya). In Destroy All Humans!, he shows a mildly perverted side when he's about to probe Miss Rockwell, but this perversion is later greatly exaggerated, likely due to him acquiring genitalia.

When with others, Crypto is very rude. Between being very sarcastic, mocking, or simply threatening people, Crypto has a few moments of genuine honesty, usually when he's in serious trouble. He is often inclined towards killing those who he simply doesn't like, unless ordered against such urges due to mission requirements. Despite his sociopathic traits, he does show that he cares about his allies. Crypto is enraged when Natalya dies on the Moon, and also mourns the Master when he fakes his death.

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