First appearance: Resident Evil (1996)
I’d love to be a hipster and tell you some obscure villain like Morpheus D. Duvall from RE: Dead Aim (2003) is the best in the series, but we all know it’s Albert Wesker.
This evil genius was the face of Resident Evil villainy from the series’ inception in 1996.
With great intelligence and superhuman abilities, Wesker was a fearsome force driving viral and parasitical disasters worldwide.
It took throwing Wesker in a volcano and shooting him with an RPG to finally take him down – a warrior’s death for one of the most hardcore villains in gaming.