Before getting his big break in "Thelma & Louise," Brad Pitt starred in a flick called "Cutting Class" -- where he played a jock who gets attacked by a psycho.
Zellweger and McConaughey weren't the only ones who spent time with Leatherface though -- one of Viggo Mortensen's first film roles was "Texas Chainsaw Massacre 3" in 1990.
Jamie Lee Curtis kicked off her career being labeled as a "Scream Queen" after starring in "Halloween," "The Fog," "Terror Train," "Prom Night" and "Halloween 2."
Shortly after "Animal House," Kevin Bacon starred in "Friday the 13th" -- where his character learned you can't have sex in a horror movie and survive.
Kelly Hu also made her big screen debut in a "Friday the 13th" flick -- falling victim to Jason Vorhees in "Friday the 13th Part VIII: Jason Takes Manhattan."
Patricia Arquette faced off against Freddy Krueger in "A Nightmare on Elm Street 3: Dream Warrior" -- and while her character lived, the role was re-cast for the 4th film.
Fellow "O.C." alum Melinda Clarke, who played Mischa's mom on the show, also got her start in horror -- as a masochistic zombie in "Return of the Living Dead 3