Best Supernatural/Monsters Hunters

Dante (Devil May Cry Series & Anime)
Hunts: Demons, Gods, Devils, Demonic Monsters. Basically any kind of demonic powered creature Dante will surely hunt and kill.

John Constantine (Constantine)
Hunts: Demons, Angels and The Devil

Dean Winchester (Supernatural)
Hunts: Demons, Vampires, Witches, Ghosts, Angels, Devils. Basically every creature that exists in supernaturalism

Sam Winchester (Supernatural)
Hunts: Demons, Vampires, Witches, Ghosts, Angels, Devils. Basically everything that exists in supernaturalism

Alan "Dutch" Schaefer (Predator)
Hunts: The Predator

The Terminator (Terminator 2: Judgement Day & Rise of The Machines)
Hunts: Machines, T-1000 and T-X

John Winchester (Supernatural)
Hunts: Demons, Vampires, Witches, Ghosts, Angels, Devils. Basically every creature that exists in supernaturalism.

Ellen Ripley (Alien Series)
Hunts: Xenomorphs (Aliens)

Alice (Resident Evil Series)
Hunts: Zombies

Daryl Dixon (The Walking Dead)
Hunts: Zombies

Darrell Edwards III/Agent J (Men In Black Series)
Hunts: Aliens

Dr. Robert Neville (I Am Legend)
Hunts: Vampires

Det. Del Spooner (I, Robot)
Hunts: Robots

Perseus (Clash of the Titans)
Hunt: Monsters

Buffy Summers (Buffy The Vampire Slayer)
Hunts: Vampires, Shapeshifters, Ghosts, Zombies and Demons.

Aragorn (The Lord of The Rings)
Hunts: Orcs, Uruk-hai, Trolls, Goblins, Sauruman (Wizard), Ringwraiths

Selene (Underworld)
Hunts: Vampires and Werewolves.

Blade (Blade Series)
Hunts: Vampires and Dracula

Lex Luthor (Smallville)
Hunts: Aliens, Meteor Freaks (Metahumans), Phantoms

Marcus Fenix (Gears of War Series)
Hunts: Locusts (A reptilian humanoids alien species)

Scar (Alien vs Predator)
Hunts: Xenomorphs (Aliens)

Wolf (Alien vs Predartor: Requiem)
Hunts: Xenomorphs (Aliens)

Claire Redfield (Resident Evil Series)
Hunts: Zombies

Denton Van Zan (Reign of Fire)
Hunts: Dragons

Trish (Devil May Cry 1, 4 & Anime)
Hunts: Demons

Clark Kent/The Blur (Smallville)
Hunts: Aliens, Meteor Freaks (Metahumans), and Phantoms

Gandalf (The Lord of The Rings)
Hunts: Orcs, Uruk-hai, Trolls, Balrog, Goblins, Nazgul, Sauruman (Wizard), Ringwraiths

Gabriel/Van Helsing (Van Helsing)
Hunts: Vampires, Werewolves and Dracula.

Damon Salvatore (The Vampire Diaries)
Hunts: Vampires and Werewolves.

Stefan Salvatore (The Vampire Diaries)
Hunts: Vampires and Werewolves.

Bayonetta (Bayonetta)
Hunts: Angels, Demons, Witches

Jill Valentine (Resident Evil)
Hunts: Zombies

Fox Mulder (The X-Files)
Hunts: Aliens, Demons, Devils, Ghosts, Spirits, Werewolves, Vampires and Zombies

Legolas (The Lord of The Rings)
Hunts: Orcs, Uruk-hai, Trolls, Goblins, Sauruman (Wizard), Ringwraiths

Dana Scully (X-Files)
Hunts: Aliens, Demons, Devils, Ghosts, Spirits, Werewolves, Vampires and Zombies

Jeanne (Bayonetta)
Hunts: Angels, Demons, Witches

Ruby (Supernatural)
Hunts: Demons, Zombies and Witches

Ellen Harvelle (Supernatural)
Hunts: Demons, Vampires, Witches, Ghosts, Angels, Devils. Basically every creature that exists in supernaturalism

Rick Grimes (The Walking Dead)
Hunts: Zombies

Richard B. Riddick (Riddick Series)
Hunts: Aliens

Kevin Brown/Agent K
Hunts: Aliens

Lady/Mary (Devil May Cry 3, 4 & Anime)
Hunts: Demons

Bobby Singer (Supernatural)
Hunts and Researches: Demons, Vampires, Witches, Ghosts, Angels, Devils. Basically everything that creature that exists in supernaturalism.

Quinn Abercromby (Reign of Fire)
Hunts: Dragons

John Conner (Terminator: Salvation)
Hunts: Machines

Abigail Whistler (Blade: Trinity)
Hunts: Vampires and Dracula

Hannibal King (Blade: Trinity)
Hunts: Vampires and Dracula

Mary Winchester (Supernatural)
Hunts: Demons, Vampires, Witches, Ghosts, Angels, Devils. Basically every creature that exists in supernaturalism

Master Chief (Halo Series)
Hunts: Aliens

Johnny Blaze/Ghost Rider (Ghost Rider)
Hunts: Demons and Devils

Jo Harvelle (Supernatural)
Hunts: Demons, Vampires, Witches, Ghosts, Angels, Devils. Basically every creature that exists in supernaturalism

Chris Redfield (Resident Evil Afterlife)
Hunts: Zombies

Rick O'Connell (The Mummy Series)
Hunts: Mummies

Eric Northman (True Blood)
Hunts: Vampires and Werewolves

Michonne (The Walking Dead)
Hunts: Zombies