Mosquita y Mari is a of a tender love between two young Chicanas that struggles to find its place in their lives and in today's world. Yolanda and Mari are growing up in Huntington Park, Los Angeles and have only known loyalty to one thing: family.
When Mari moves in across the street from Yolanda, they maintain their usual life routine, until an incident at school thrusts them into a friendship and into unknown territory. As their friendship grows, a yearning to explore their strange yet beautiful connection surfaces. Lost in their private world of unspoken affection, lingering gazes, and heart-felt confessions, Yolanda's grades begin to slip while Mari's focus drifts away from her duties at a new job.
Mounting pressures at home collide with their new-found desires thus driving Yolanda and Mari's relationship to the edge, forcing them to choose between their obligations to others and staying true to each other.