After his death in first Metal Gear Solid, he would return in the other games as a ghost he would try to force the player to do something with the controller.
Dante in the Devil May Cry Series is a typical half demon that cracks jokes, at other characters that are the most gullible. Some times leading breaking the 4th wall.
Just take a look at the begging of this episode at 4:33 and from there on it gets so out of control.
In every form of entertainment, there will always be a character that will stand out from the rest, and go out of character. Here is my Top 6 Characters that Break the Fourth Wall.