Frankie Heck, a wife and mother of three. Frankie is the central character in the show and provides the voice-over narration. She is a devoted wife and mother and sees family as the most important thing in her life. Her motto, "You do for family," guides her daily routine, despite the frustrations she encounters with her three kids and her older, ailing relatives who depend on her for their needs.
"We're not rich enough to get a divorce. So we're gonna have to have a fight."
Mike Heck, Frankie's husband, known for his blunt honesty and somewhat old-fashioned ways. Mike works at the quarry as the manager, and despite his no-nonsense approach to work and family, he is a devoted husband who always seems to come through for Frankie when she needs it most.
"Why do we gotta go looking for trouble? I'm pretty sure it knows our address."
Axl Heck, athletic teenage son of Frankie and Mike, who can't be bothered to put on more than boxer shorts most of the time at home. He is the stereotypical older brother: sarcastic, lazy, and mean to his siblings.
"Eskimos aren't even real. They're just in stories like leprechauns and trolls."
Brick Heck, youngest child, who is an unusual boy who loves to read and has a habit of whispering the last words in a sentence to himself. He is exceptionally intelligent, but is easily distracted, leading him to procrastinate on – or just forget – his homework assignments and projects.
"Cool! A manual. And it's in German, Japanese and French!"
Brad - is Sue's flamboyant ex-boyfriend. They dated during Thanksgiving but shortly broke up when Sue found out Brad is a smoker. Frankie and Mike both suspect he is gay; however, both Sue and Brad seem oblivious of their suspicions.