My favorite superhero ever. His wit in the face of formidable enemies of all kinds lightens up the mood to an otherwise heartbreakingly tragic comic. Spider-Man faces more trials outside of his villain battling than most superheroes, as the drama of his life is far from over just because he gets bitten by a radioactive spider.
The Phantom was THE original superhero, two years before Superman even came along. That alone should make him worth a little attention. Also, his early adventures were brilliantly written and rival even the best of what we've done with the genre since. He's witty, fearless, and virtuous. All in all, he's likeable as much as he is influential.
If you don't always believe in America, at least you can believe in what Cap stands for. In fact, he's defied America itself in the name of the principles he believes it should embody - in the case of the Marvel universe's Civil War, wherein he led the side of superheroes who were against an act which would require them to give up their secret identities.
He'll never be surpassed in greatness by any other Belmont that goes after Dracula. Before Alucard and Soma Cruz, Simon was the character identified with the series. I'm still hoping for him to be included in the next Super Smash Bros.
Sonic is fast and egotistical, with more than enough attitude than any one hedgehog should ever need. He's a very good hero who's devoted to protecting Mobius from evil (namely, Robotnik), but he also derives a lot of pleasure out of running circles around his enemies.
Amy Rose is a fun, strong character who's hopelessly in love with Sonic. She's very aggressive about it. In the comics, her love is in vain as Sonic is into Sally. In the video games, there's no such competition and eventually the indication is that he'll come around.
Though Amy's dedicated, she can't change the fact that Sonic will always think of Sally before any other female animal. Sally Acorn's a tomboy princess (wow, almost seems like an oxymoron) who certainly has plenty of suitors herself. Along with Sonic, Antoine D'Coolette, and Rotor Walrus, she was one of the original four Freedom Fighters, so she and Sonic have some definite history.
Tails was my favorite Sonic character as a kid. He's a great side kick for true blue, though in the comics his role has been less significant in the last few years. I'm hoping he'll eventually part with Sonic and have his own series, like Robin did as Nightwing.
Knuckles was Sonic's original rival, and the only supporting character to have his or her own ongoing solo comic book series. His Angel Island-Echidna mythology is very in-depth thanks to the freedom given to Ken Penders when writing for the character (leading to his liking writing Knuckles the Echidna more than Sonic the Hedgehog). There are still many mysteries to the Echidna race's past as well as villains to keep Knux busy and friends to help him. With a writer like Ian Flynn, another series could really work.
Shadow may have elements of Knuckles, but he has a unique backstory and character. The death of his friend Maria has lead to his dark emotional state and resentment of all living things. With him off working for G.U.N. with Team Dark on another part of Mobius, I believe a Shadow the Hedgehog ongoing solo comic book series would be the smartest idea right now due to his popularity.
Silver, coming from a dystopian future, zone and time hops to aid in epic conflicts of every kind. While Shadow may have the popularity bit down, a Silver series has the most potential. Silver could go back to historical Mobius Prime and meet the figures of old that are spoken of in its historical texts. He could also go to every stinkin' zone in the multiverse! The Sonic the Hedgehog multiverse itself is well-explained and never existed as a result of convoluted continuity issues, as in the DC universe. I'd like to see a Silver series most, though I acknowledge that the waters must be tested with less risky main protagonists Knuckles and Shadow first.
Mighty was one of the prototypes character designs for the Sega platformer to rival Nintendo's Mario, before the-powers-that-be chose Sonic. He's easy-going, without all the egotism present in Sonic. He can also kick off of walls in the games, which gives him an ability that's actually unique, as opposed to the other supporting characters in Knuckles' Chaotix.
And you thought Superman was overpowered! As Goku came face to face with increasingly powerful enemies, he had to learn new techniques and transcend the Super Saiyan form as many times as he could muster. Akira Toriyama isn't as satisfied with his later work on the series (which we in the Western world know as "Dragon Ball Z"), but it's proven to be the more popular of the two phases of Goku's life recounted in the manga.
Uzumaki Naruto has more personal demons than one. Starting out life as a rude, rebellious social outcast, he soon becomes loved by the Konoha townsfolk through his achievements and his rough edges are evened out, forming a humble, heroic young man.
The adventures of Straw Hat Luffy totally are off the wall, mixing the over-the-top silly with the intensely serious for a perfect balance. One Piece is just about my favorite manga alongside Yu-Gi-Oh!, and it's certainly the longest running of my many favorites.
Writer/artists Kazuki Takahashi would constantly create a new game for Yugi Motou as the initial seven volumes worth of comics came out, bringing it to life with his distinctive style. Then the Duel Monsters game won out, and the rest of the series focused on that. Which wasn't bad, though I wish spin-off series like GX and 5DS would add some other new games to the mix.
Flip the Frog is my favorite Golden Age cartoon character, created by Ub Iwerks right after leaving Walt Disney's company. He gets into lots of wild, goofy adventures, geared less exclusively toward children than the Disney-Iwerks shorts.
Bender's your typical loud-mouthed, alcoholic, female-robotizizing (because I couldn't find a real word specific to female robots) hunk of metal. He's not overly sentimental or anything. He's one unapologetic personality that I appreciate.