NAME: Mudflap, Skids, Wheelie, Judy Witwicky, Leo Spitz, the list goes on.
PERSON RESPONSIBLE: Reno Wilson, Tom Kenny, Tom Kenny, Julie White, Ramon Rodriguez, etc.
QUOTE OF PURE ANNOYANCE:
"Bust a cap in his ass, lock him in the trunk, ain't nobody gon' know nothin', know what I mean?" - Mudflap
"Why don't you get a haircut with yo' bitch ass?!" - Skids
"Nice Wheelie, say my name, say my name..." - Wheelie as he humps Mikaela's leg
"I'm not impressed by your perverted mouth breathing." - Judy
"How many times can you get tazered in the nuts before you can't have kids?" - Leo
MOMENT OF PWNAGE: Bumblebee clashes the twins together and throws them out, Wheelie gets bitchslapped by Megan Fox, nothing special happens to Judy and Leo gets tased by Agent Simmons.

NAME: Jar Jar Binks
PERSON RESPONSIBLE: Ahmed Best
QUOTE OF PURE ANNOYANCE: "MEESA GOIN' HOOOOME!"
MOMENT OF PWNAGE: Gets left to fall down a waterfall. Unfortunately, this is only in The Phantom Edit. :( He does get killed by Darth Vader in Robot Chicken Star Wars, but then he comes back as a ghost.

NAME: Herman Ferguson
PERSON RESPONSIBLE: Rob Schneider
QUOTE OF PURE ANNOYANCE: "Eat Dredd! He works out!"
MOMENT OF PWNAGE: A robot shoots him. Also, Dredd says to Ferguson, "You talk too much."

NAME: Arpid
PERSON RESPONSIBLE: Grant Heslov
QUOTE OF PURE ANNOYANCE: "You see, I am about to escape, while you on the other hand are about to die a horrible death, for leaving me to die last night!"
MOMENT OF PWNAGE: Gets socked by the Rock.

(Yes, he is a comic relief. Kinda. And he annoyed the hell out of me.)
NAME: Hannibal King
PERSON RESPONSIBLE: Ryan Reynolds
QUOTE OF PURE ANNOYANCE: "I can tell you two things. One, your hairdo is ridiculous. Two, I ate a lot of garlic, and I just farted. Silent but deadly."
MOMENT OF PWNAGE: Gets beaten up various times, only to show his inner badass.

NAME: Charlie Frost
PERSON RESPONSIBLE: Woody Harrelson
QUOTE OF PURE ANNOYANCE: "It's the apocalypse. End of days. The Judgement Day, the end of the world, my friend. Christians called it the rapture, but the Mayans knew about it, the Hopis, the I Ching, the Bible, kind of..."
MOMENT OF PWNAGE: A huge volcanic rock hits him! AWESOME! :D

NAME: Ruby Rhod
PERSON RESPONSIBLE: Chris Tucker
QUOTE OF PURE ANNOYANCE: "What's wrong with you? What you screamin' for? Every 5 minutes there's somethin', a bomb or somethin'. I'm leavin'. bzzzz."
MOMENT OF PWNAGE: Forgot...

NAME: Limbo
PERSON RESPONSIBLE: Paul Giamatti
QUOTE OF PURE ANNOYANCE: "Are you trying to put me out of business? These are the skankiest, scabbiest, scuzziest humans I've ever seen."
MOMENT OF PWNAGE: Gets beaten up a lot.