Live-action couples from film and TV that are of different species. I welcome suggestions. There are a few spoilers on here-but they've been blacked out in case you just don't want to know yet. :)
Pygar-Angel/Barbarella-Human
Barbarella- "I'm from the planet Earth. My name is Barbarella."
[He reaches out and caresses her face.]
Pygar- "But you're soft and warm! We're told that Earth beings are cold."
Barbarella- [slyly smiling] "Not all of us."
Danika-Vampire/Jack-Human
Jack: "But how was your day? What'd you do?"
Danika: "You know. Transformed into a bat for a while, took a nap in my coffin. The usual."
Leeloo-Supreme Being/Korben-Human
Korben Dallas: "What's your name?"
Leeloo: "Leeloo Minai Lekarariba-Laminai-Tchai Ekbat De Sebat."
Korben Dallas: "Good. That... that whole thing's your name, huh? Do you have, uh... a shorter name?"
Leeloo: "Leeloo."
Tonks-Witch/Lupin-Werewolf
Lupin: "I am not being ridiculous. Tonks deserves somebody young and whole."
Mr. Weasley: "But she wants you, and after all, Remus, young and whole men do not necessarily remain so."
Liz-Human/Hellboy-Demon
Hellboy: "Liz..."
Liz Sherman: "Don't try to talk."
Hellboy: "No, you need to hear this. I know what's important. It's you. I can turn my back on the world, all of it... as long as you stay with me."
Liz Sherman: "I'll stay with you. You're the best man I know."
Hellboy: [smiles] "Man..."
Bruce-Hulk/Betty-Human
Betty Ross: [yells at taxi driver] "Asshole!"
Bruce Banner: "You know, I know a few techniques that could help you manage that anger effectively."
Betty Ross: "You zip it. We're walking."
Bruce Banner: "Ok."
Aragorn-Human/Arwen-Elf
Arwen: "I would rather share one lifetime with you than face all the ages of this world alone."
[hands him her pendant]
Arwen: "I choose a mortal life."
Aragorn: "You cannot give me this."
Arwen: "It is mine to give to whom I will. Like my heart."
Lestat-Vampire/Jesse-Human
Lestat: "You're beautiful to me because you're human. Your frailty. Your short years. Your heart. All that suddenly seems more precious than anything I've ever known."
Jesse: "I'm not as precious as you think."
Madison-Mermaid/Allen-Human
Madison: "Allen, don't feel guilty."
Allen: "Guilty? About what?"
Madison: "About not loving me anymore."
Allen: "Oh, Madison. All the time we were together, you always knew how I was feeling. Can't you tell now?" [Madison smiles, and they kiss]
Uhura-Human/Spock-Alien
Spock: [standing across Lt. Uhura before he and Kirk are about to be beamed onto the Romulan warship] "I will be back."
Lt. Nyota Uhura: [leaning in] "You better be! I'll be monitoring your frequency."
Spock: [actually quite emotional] "Thank you, Nyota."
James T. Kirk: [after Uhura leaves] "So her first name's Nyota?"
Spock: "I have no comment on the matter."
Edward-Vampire/Bella-Human
Edward Cullen: "And so the lion fell in love with the lamb."
Isabella Swan: "What a stupid lamb."
Edward Cullen: "What a sick, masochistic lion."
Lucian-Werewolf/Sonja-Vampire
Lucian: "But I failed you!"
Sonja: "No, Lucian my love, you have not failed me. The choices I made have led me here and to you! You said yourself that there were risks you were willing to take for me... as was I for you... for us."
Dick Solomon-Alien/Mary Albright-Human
Dr. Mary Albright: "If we're over the hill, we might as well enjoy the ride down."
Dr. Dick Solomon: "Thank you for saying we."
Dr. Mary Albright: "It just slipped out."
Athena-Cylon/Helo-Human
Sharon: "I made a choice to wear a uniform, to be a person."
Helo: "You were a person before you put on that uniform, okay? You were a person before I fell in love with you. You don't have to prove that."
Sharon: "I have to prove it every day."
Six-Cylon/Gaius-Human
Number Six: [ominously] "God has a plan, Gaius. He has a plan for everything, and everyone."
Buffy-Human/Angel-Vampire
Angel- "You really don't care what happens a year from now? Five years from now?"
Buffy- "Angel, when I look into the future, all I see is you! All I want is you."
Angel- "I know the feeling."
Spike-Vampire/Buffy-Human
Buffy: "Tell me you love me."
Spike: "I love you... you know I do."
Buffy: "Tell me you want me."
Spike: [huskily] "I always want you."
Willow-Witch/Oz-Werewolf
Oz: "You mean... You'd still..."
Willow: "Well, I like you. You're nice and you're funny. And you don't smoke. Yeah, OK, werewolf. That's not all the time. I mean three days out of the month I'm not much fun to be around either ."
Oz: "You are quite a human."
Willow: "So I'd still if you'd still."
Oz: "I'd still. I'd very still."
Willow: "OK, no biting though."
Xander-Human/Anya-Demon
Anya: "Will you still make me waffles when we're married?"
Xander: "No, I'll only make them for myself. But, by California law, you will own half of 'em."
Beth-Human/Mick-Vampire
Beth: "It's just that being on the hunt with you is kinda fun."
Mick St. John: "Yeah, it's just a giant thrill ride that never ends. You know, sometimes it does end, with terrible screams and blood shed."
Beth: "Still, we make a good team..."
Max-Alien/Liz-Human
Liz: "How is it possible I could be the happiest I've ever been in my entire life and now the saddest, all at one time?"
Max: "I think that's what being in love is."
Worf-Alien/Jadzia Dax-Symbiotic Life Form
Lt. Commander Jadzia Dax: "I know how much your career means to you."
Lt. Commander Worf: "You come first - before career, before duty, before anything. I do not regret what I did; and I would do it again."
Bill-Vampire/Sookie-Fairy/Human
Sookie Stackhouse: "Well, I-I'm-I'm Sookie Stackhouse, and I'm a waitress. What's your name?"
Bill Compton: "Bill."
Sookie Stackhouse: [giggles] "Bill? I thought it might be Antoine, or Basil, or-or-or like Langford, maybe. But, Bill? Vampire Bill!"
Sookie-Fairy/Human/Eric-Vampire
Eric Northman: "You broke my nose!"
Sookie Stackhouse: "You're a vampire. You'll heal in five minutes."
Eric Northman: "I know I'm a vampire, Snookie."
Sookie Stackhouse: "It's SOOKIE!"
Hoyt-Human/Jessica-Vampire
Hoyt Fortenberry: "This might sound kind of funny, but I was just sitting there thinking, "How come you don't ever meet a nice girl, Hoyt?" And then you just walked right in."
Jessica Hamby: "How do you know I'm a nice girl?"
Hoyt Fortenberry: "Cause of your smile, I guess. You can tell a lot about someone by the way they smile."
Elana-Human/Stefan-Vampire
Stefan Salvatore: "That's what you want?"
Elena Gilbert: "Yes, it is. Because I don't want it to be like this. I don't want to feel like this. But I can't. With everything that's happened, I can't lose the way I feel about you."
Damon-Vampire/Elana-Human
Elena Gilbert: "Where were you, Damon?"
Damon Salvatore: "I shouldn't have left. I promise you, I will never leave you again."
Maybe Dick Solomon and Mary Albright from tv show '3rd Rock from the Sun' ?
http://www.listal.com/viewimage/4068096
but come on, Clark-kryptonian
and The Doctor-Time Lord
;P
And how about Aragorn and Arwen from The Lord of the Rings? Human and Elf!
http://www.listal.com/viewimage/4593762
What about Jessica Rabbit and Roger Rabbit?
incrediblejeff-I'm only doing live-action couples, but thanks for the suggestion!
Alice Wesker-LOL.