Granted, she's had leading roles, but she deserves the spotlight as someone other than the romantic interest for the male lead (Dark Knight, Crazy Heart, etc.).
Already a talented voice actress (Bob's Burgers, small roles in The Simpsons, American Dad), it's time for all of her to get some face time on celluloid.
She turned down a role in Clerks II because she feared she might be typecast in "girlfriend" roles. That she never did get that starring turn in a film is an injustice to all who appreciate good potty humor.