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actors and celebrities who appeared in Star Trek
 6.1 Wallace Shawn, best known for playing Vizzini in "A Princess Bride", was Zek the Grand Nagus of the Ferengi Alliance in "Star Trek: Deep Space 9".
 
5 Mick Fleetwood of Fleetwood Mac fame played a duplicitous, fish loving Antedean Dignitary in "Star Trek: The Next Generation" episode "Manhunt".
 
5.6 Andrea Martin, the actress and comedienne, plays Moogie, Quark and Rom's Ferengi society defying mother, in the "Star Trek: Deep Space Nine" episode "Family Business".
 
8.6 Stephen Hawking plays himself in a game of poker with Sir Isaac Newton, Albert Einstein and Data in the "Star Trek: The Next Generation" Episode "All Good Things...". Hawking currently holds the position of Lucasian chair of Mathematics at Cambridge University, a position formerly held by Sir Isaac Newton and held by Data in future scenes of "All Good Things...".
7.3 Seth MacFarlane of "Family Guy" and "American Dad" twice cameoed on "Star Trek: Enterprise" as a Starfleet officer.
6.5 Dwayne "The Rock" Johnson played a Pendari champion (a kind of gladiator) in the "Star Trek: Voyager" episode "Tsunkatse".
6.8 Punk rocker Iggy Pop played Yelgrun, the Vorta overseer working for the Dominion, in the "Star Trek: Deep Space Nine" episode "The Magnificent Ferengi".
 
7 Bryan Singer, director of "X-Men" and "X2", appeared as a tactical officer in "Star Trek: Nemesis".
 
6.3 Christian Slater plays a night duty officer in "Star Trek VI: The Undiscovered Country
 
6.5 Kelsey Grammer of "Cheers" and "Frasier" played Captain Morgan Bateson, a captain of the Enterprise whose ship was stuck in a time loop, in the "Star Trek: The Next Generation" episode "Cause and Effect".
 
6.1 Ken Jenkins, most known for his role as Dr. Bob Kelso on "Scrubs", played Dr. Paul Stubbs in "Star Trek: The Next Generation" episode "Evolution"
 
6.9 Kirsten Dunst, best known for playing Mary Jane Watson in the Spider-Man films, played in the "Star Trek: The Next Generation" episode "Dark Page" when she was just eleven-years-old.
 
5.4 Kirstie Alley, the "Cheers" actress and noted Scientologist, had her feature film debut as Saavik in "Star Trek II: The Wraith of Khan".
 
6.5 Jason Alexander, who played George on "Seinfeld", played "Kurros" in the "Star Trek: Voyager" episode "Think Tank".
 
7.4 Christopher Lloyd, best known for his role as "Doc" Brown in the "Back to the Future" trilogy, played Klingon Commander Kruge in the film "Star Trek III: The Search for Spock".
 
7.1 A young Ashley Judd played ensign Ensign Robin Lefler, a love interest and friend of Wesley Crusher, in two episodes of "Star Trek: The Next Generation" "Darmok" and "The Game."
 
6.2 Teri Hatcher played Lieutenant B.G. Robinson, a transporter officer who is seduced by a rogue, in the "Star Trek: The Next Generation" episode "The Outrageous Okona".
 
5.7 Sarah Silverman is a stand up comedienne who played Rain Robinson in two episodes of "Star Trek: Voyager" "Future's End" and "Future's End: Part 2".
 
7.5 Tom Morello of Rage Against the Machine and Audioslave played uncredited officer in "Star Trek: Insurrection" and a crewman in the "Star Trek: Voyager" episode "Good Shepard"
 
7.3 Kim Catrall, made famous by "Porky's" and "Sex and the City", played Valeris in "Star Trek VI: The Undiscovered Country".
 
6.7 Kurtwood Smith, best known for "That '70s Show" and "Dead Poets Society" has played several roles in "Star Trek". He played the Federation president in "Star Trek VI: The Undiscovered Country", Thrax, Odo's predecessor in the "Star Trek: Deep Space 9" episode "Things Past" and Annorax in the "Star Trek: Voyager" episode "Year of Hell" and "Year of Hell: Part 2".
 
6.7 James Cromwell played multiple roles in the Star Trek franchise. Most notable was his performance as Zefram Cochrane in "Star Trek: First Contact" as the first human to create a warp drive.
 
6 Nikki Cox who is best known for her role on the sitcom "Unhappily Ever After" played Sarjenka, a little girl on a doomed planet communicating with Data, in the "Star Trek: The Next Generation" episode "Pen Pals".
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I'd have to say I like DS9 the most of all the Star Treks overall though.